Stopped: This study was terminated due to the departure of the Principal Investigator from the Sponsoring institution.
The mechanism by which vision loss in glaucoma occurs is still unknown, but it is clear that increased Intraocular Pressure (IOP) is a major risk factor. It is also thought that the lamina cribrosa (LC) is a site of primary damage during the pathogenesis of the disease. The changes caused by intraocular pressure (IOP) modulation at the level of the optic nerve head and LC will be evaluated in the present study. Subjects with keratoconus exhibit abnormal collagen properties that can impair their LC behavior. By evaluating their lamina biomechanical response we can advance our understanding on the role of the lamina in glaucoma pathogenesis. A better understanding of the process will ultimately lead to improved detection and management of glaucoma. It is hypothesized that subjects with keratoconus have an abnormal biomechanical response of the lamina cribrosa in response to IOP modulation.
Age range
18 Years – 90 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Number of Patients With Tissue Deformation in ONH Region
Timeframe: 1 Day
Number of Patients With Tissue Deformation in Peripapillary Region
Timeframe: 1 Day
Change in Rim Area (ONH Region) Under Elevated Intraocular Pressure
Timeframe: 1 Day
Change in Rim Area (Peripapillary Region) Under Elevated Intraocular Pressure
Timeframe: 1 Day
Change in Cup Depth (ONH Region) Under Elevated Intraocular Pressure
Timeframe: 1 Day
Change in Cup Depth (Peripapillary Region) Under Elevated Intraocular Pressure
Timeframe: 1 Day
Change in Lamina Cibrosa Area (ONH Region) Under Elevated Intraocular Pressure
Timeframe: 1 Day
Change in Lamina Cibrosa Area (Peripapillary Region) Under Elevated Intraocular Pressure
Timeframe: 1 Day