UnknownNot Applicable

Frozen Blastocyst Transfer Using Conventional Timing Versus Timing by Endometrial Receptivity Analysis

United States800 participantsStarted 2018-04-25

Plain-language summary

To assess live birth after embryo transfer according to an individual's ERA results as opposed to routine protocol for frozen embryo transfer (FET) cycles.

Who can participate

Age range30 Years – 40 Years

SexFEMALE

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Inclusion criteria

✓. Signed informed consent
✓. Female age between 30 and 40 years and deemed likely by her physician, based on ovarian reserve testing, to produce at least one euploid blastocyst via one IVF/intracytoplasmatic sperm injection (ICSI) cycle
✓. Having ≥ 1 euploid embryo available for embryo transfer
✓. Standard eligibility criteria to undergo IVF and FET at Shady Grove Fertility Center.

Exclusion criteria

✕. Known uterine factor impacting the endometrium
✕. Use of surgically aspirated sperm for fertilization
✕. Presence of any clinically relevant systemic disease that contraindicates assisted reproductive technology.
✕. Since the subject last had a live birth (if any), there have been more than two embryo transfers that have not resulted in ongoing pregnancy
✕. Body mass index \>40 kg/m2 at screening
✕. Recurrent pregnancy loss, defined as two or more clinical pregnancy losses without live birth
✕. Planned testing of embryos for single gene disorder(s) or structural chromosome rearrangements
✕. Currently breast feeding, pregnant, or contraindication to pregnancy

What they're measuring

The primary outcome measure of this clinical trial is to assess live birth after euploid embryo transfer according to an individual's ERA result as opposed to routine protocol for frozen embryo transfer (FET) cycles.

Timeframe: From date of randomization until live born infant at an estimated gestational age of at least 23 weeks or greater

Trial details

NCT IDNCT03558399

SponsorShady Grove Fertility Reproductive Science Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-09-23

View on ClinicalTrials.gov More Implantation Failure trials