An Early Bactericidal Activity, Safety and Tolerability of GSK3036656 in Subjects With Drug-sensitive Pulmonary Tuberculosis

Inclusion Criteria: * Subjects must be 18 to 65 years of age inclusive, at the time of signing the informed consent. * In addition, subjects recruited into cohorts that are planned to undergo fluorodeoxyglucose (FDG) positron emission tomography/ Computed Tomography (PET/CT) must be \>=25 years of age, at the time of signing the informed consent. * New episode of untreated, rifampicin-susceptible pulmonary tuberculosis. * A chest X-ray picture which in the opinion of the Investigator is consistent with tuberculosis. * At least one sputum sample positive on direct microscopy for acid-fast bacilli (at least 1+ on the International Union Against Tuberculosis and Lung Disease/ World Health Organization \[IUATLD/WHO\] scale) or molecular test (Xpert MTB/ rifampicin) with result of either medium or high positive for MTB: Ability to produce an adequate volume of sputum as estimated from an overnight sputum collection sample (estimated 10 milliliter or more); estimated from a spot sputum sample at screening; confirmed at the first overnight collection; if less than 10 milliliter is collected overnight this may be repeated once. * Normal echocardiogram or echocardiogram with normal left ventricular function with at most trace to mild valvular regurgitation and no valvular stenosis. * Within the normal range for the assay for troponin and b-type natriuretic peptide at screening. * Body weight (in light clothing and with no shoes) between 40 and 90 kilograms, inclusive, at screening. *…