We wish to determine to what extent magnesium, thiamine and transketolase activity are affected by the Systemic Inflammatory Response (SIR). The knee arthroplasty model affords the ideal study design, as surgery generates an inflammatory response. Blood samples are drawn preoperatively and for up to four days post operatively, and again at three months post-operation.
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serum magnesium
Timeframe: three months
thiamine
Timeframe: three months
erythrocyte transketolase activity
Timeframe: three months