Effect of Granulocyte Colony-stimulating Factor on Clinical Pregnancy Rate in Patients With Endometriosis

Inclusion Criteria: * Cases of infertility, older than 20 years of age and not older than 40 years. * Body mass index (BMI): 20-29. * Women diagnosed with endometriosis (diagnosis based on ultrasound or laparoscopy or both) * Recurrent implantation failure (failure to conceive following two embryo transfer cycles, or cummulative transfer of \>10 good quality embryos) * Normal ovulatory cycles (as proven by folliculometry and/or mid luteal serum progesterone), good ovarian reserve (as proven by early follicular FSH and AMH) * Normal uterine cavity as assessed by ultrasonography, hysterosalpingography, or hysteroscopy * Normal hormonal profile (serum PRL, TSH, thyroid hormone) * Normal semen analysis of the partner * Infertility after one year of unprotected intercourse * High-quality embryos were transplanted Exclusion Criteria: * Congenital or acquired uterine abnormalities (e.g. septate, bicornuate, fibroid uterus, uterine polyp \& Asherman Syndrome) * Congenital or acquired tubal abnormalities (e.g. hydrosalpinx or pyosalpinx) * Contraindication for G-CSF (renal disease, sickle cell disease, or malignancy history, upper respiratory tract infection, pneumonia, or chronic neutropenia) * Thrombophilia