CompletedNot Applicable

Expression of the Inhibitory Receptors on Lymphocytes T Cells After Lung Cancer Surgery.

France31 participantsStarted 2018-06-14

Plain-language summary

Postoperative pneumonia is one of the most common complications after lung cancer surgery and associated with a morbidity and mortality. Postoperative lymphopenia has been recently identified as one of risk factors for postoperative pneumonia. According to recent studies in polytrauma, cancer or septic shock, T cells dysfunction may be related to high expression of inhibitory receptors on lymphocytes.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient ≥ 18 years undergoing lung cancer surgery by thoracoscopy Exclusion Criteria: * Patient under guardianship/curatorship * Patient who received of radiotherapy or chemotherapy in the last 6 months * Patient under immunosuppressive treatment or dose of corticoids over 10 mg/day prednisolone or equivalent * Patient with history of malignant blood disease or auto-immune disease * Patient suffering from HIV infection and * Patients with pre-operative infection * Patient with an empiric antibiotic therapy introduced at operating room

What they're measuring

PD-1, TIM-3, CTLA4 on CD4/CD8 lymphocytes

Timeframe: Days 0, 1, 3

Trial details

NCT IDNCT03549546

SponsorCentre Hospitalier Universitaire de Saint Etienne

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-02-06

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