CompletedNot Applicable

Fructose Supplementation in Carriers for Hereditary Fructose Intolerance

Belgium12 participantsStarted 2018-05-01

Plain-language summary

This study aimed to examine metabolic response to a short-term fructose enriched diet in carriers for hereditary fructose intolerance compared to controls. Effects of fructose coffees will be assessed in 7 healthy volunteers and 7 subjects with heterozygous mutation for ALDOB gene in a randomized, controlled, crossover trial.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Case subjects: Heterozygous carriers for ALDOB mutation confirmed by molecular analysis * Control subjects: healthy individuals matched for weight and age to subjects Exclusion Criteria: * Fasting glucose \> 7.0 mmol/L * Fasting triglycerides \> 4.0 mmol/L * Chronic renal insufficiency (eGFR \< 50 ml/min) * Drugs * Women who are pregnant or breast feeding * For women: lack of safe contraception * Alcool consumption \> 30g/d * Inability to discern

What they're measuring

Metabolite concentration

Timeframe: Time Frame: -30 min before ingestion of a test meal to 120 min after ingestion of a test meal

Trial details

NCT IDNCT03545581

SponsorUniversity of Lausanne

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-12-01

View on ClinicalTrials.gov More Hereditary Fructose Intolerance trials