Study on Neurocognitive Plasticity in Patients With Focal and Drug-resistant Epilepsy (NCT03543267) | Clinical Trial Compass
CompletedNot Applicable
Study on Neurocognitive Plasticity in Patients With Focal and Drug-resistant Epilepsy
France37 participantsStarted 2017-10-21
Plain-language summary
This study consist of define anatomo-functional reorganization (plasticity) profiles for the mentioned cognitive functions, before surgery (chronic plasticity induced by the epileptogenic zone) in patients with drug-resistant epilepsy.
For that, patients will have 2 MRI examinations, one before surgery and the second, between 3 and 8 months after surgery.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with diagnosis of pharmaco-resistant focal epilepsy
* Patient candidate for surgery to resect the epileptogenic zone
* Patients affiliated to a social security scheme or beneficiaries of such a scheme
* Patients with French as their mother tongue
* Patients who have given signed informed consent before performing any procedure related to the study.
Exclusion Criteria:
* Contraindication to performing an MRI:
* Intellectual disability objectified by a Mini Mental Score (MMS) score \<24 in the year preceding inclusion,
* Existence of a severe condition in general: cardiac, respiratory, hematological, renal, hepatic, cancerous,
* Participation in other research protocols underway with exclusion period or in the previous week,
* Persons referred to in Articles L1121-5 to L1121-8 of the Public Health Code.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
to define anatomo-functional reorganization (plasticity) profiles by functional MRI for the mentioned cognitive functions, before surgery (chronic plasticity induced by the epileptogenic zone) in patients with drug-resistant epilepsy.