Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric AKI (NCT03541785) | Clinical Trial Compass
By InvitationNot Applicable
Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric AKI
United States420 participantsStarted 2018-07-01
Plain-language summary
This study follows a group of patients admitted to the PICU who are identified as being at risk for developing acute kidney injury. The investigators will use risk-stratification, biomarker testing, and a functional assessment to predict patients who will become fluid overloaded and develop acute kidney injury.
Who can participate
Age range
3 Months – 25 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Admitted to the Pediatric Intensive Care Unit (PICU)
* Renal Angina Index (RAI) greater than or equal to 8
* Urine NGAL greater than or equal to 150 ng/mL
* Indwelling urinary catheter
Exclusion Criteria:
* Evidence of volume depletion
* Baseline Chronic Kidney Disease (CKD) Stage IV or V (estimated GFR \<60 mL/min/1.73m2)
* History of kidney transplantation
* Active DNR order or clinical team is not committed to escalating medical care
* Known history of allergic reaction to furosemide (only for FST)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Clinical Decision Support Success (CDS)
Timeframe: 48 hours of PICU admission
Trial details
NCT IDNCT03541785
SponsorChildren's Hospital Medical Center, Cincinnati