By InvitationNot Applicable

Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric AKI

United States420 participantsStarted 2018-07-01

Plain-language summary

This study follows a group of patients admitted to the PICU who are identified as being at risk for developing acute kidney injury. The investigators will use risk-stratification, biomarker testing, and a functional assessment to predict patients who will become fluid overloaded and develop acute kidney injury.

Who can participate

Age range3 Months – 25 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Admitted to the Pediatric Intensive Care Unit (PICU) * Renal Angina Index (RAI) greater than or equal to 8 * Urine NGAL greater than or equal to 150 ng/mL * Indwelling urinary catheter Exclusion Criteria: * Evidence of volume depletion * Baseline Chronic Kidney Disease (CKD) Stage IV or V (estimated GFR \<60 mL/min/1.73m2) * History of kidney transplantation * Active DNR order or clinical team is not committed to escalating medical care * Known history of allergic reaction to furosemide (only for FST)

What they're measuring

Clinical Decision Support Success (CDS)

Timeframe: 48 hours of PICU admission

Trial details

NCT IDNCT03541785

SponsorChildren's Hospital Medical Center, Cincinnati

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2028-06-30

View on ClinicalTrials.gov More Acute Kidney Injury trials