CompletedNot Applicable

Clinical Monitoring, MRI and Neuro-Ophthalmology of a Cohort of Patients With a Clinically Isolated Syndrome (CIS)

France134 participantsStarted 2014-09

Plain-language summary

The purpose of this study is to develop tools to detect, measure, monitor and predict axonal damage in the course of CIS and during Multiple sclerosis (MS), in order to be able to consider as early as possible an adaptation of the background treatment in patients with MS. patients with radiological criteria of poor long-term clinical course.

Who can participate

Age range18 Years – 50 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Any patient who has had a CIS of less than 4 months (+/- 15 days), with at least 1 inflammatory lesion on his initial brain MRI or with normal brain MRI associated with the presence of oligoclonal bands in the CSF, Exclusion Criteria: * Atypical CIS for a first relapse of multiple sclerosis (extensive myelitis, bilateral retrobulbar optic neuritis immediately) * CIS dating more than 4 months (+/- 15 days) * Corticotherapy in the last 4 weeks

What they're measuring

severity of the disease defined by Expanded Disability Status Scale (EDSS) ≥ 2.0

Timeframe: At 5 years

Trial details

NCT IDNCT03541226

SponsorUniversity Hospital, Lille

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-01

View on ClinicalTrials.gov More Clinically Isolated Syndrome trials