Evaluation of Libramed in Obesity Treatment

Inclusion Criteria: * BMI 30.0-39.9 kg/m2, * serum fasting glucose and insulin in normal ranges (- glucose ≤ 100 mg/dl, insulin ≤ 15 uIU/ml) * HOMA-IR \< 2.5 (normal range for insulin sensitivity among Polish population), * stable body mass in the last 3 months (not more than 2 kg), * do not use any hypocaloric diet in the last 6 months, * not changed then realized before physical activity in the last 3 months, * the lack of any known comorbidities, * do not use any drugs including contraceptive * capability to understand the study procedures and provide written informed consent. Exclusion Criteria: * All chronic and acute disease of the digestive tract in medical history, * smoking, * more than 3 alcoholic drinks per week (bear, glass of wine, and 50 ml vodka) * no patient co-operation.