The purpose of the study is to investigate in vivo whether a high-dose vitamin D3 oral bolus (2000 micrograms) produces marked vitamin D receptor target gene expression response and whether there is large inter-individual variation. These effects are compared to in vitro treatment of peripheral blood mononuclear cells from these subjects with 25(OH)D.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
In vivo change from baseline in vitamin D target gene expression in the subjects
Timeframe: 24 hours after the baseline
In vitro change from baseline in vitamin D target gene expression in peripheral blood mononuclear cells
Timeframe: 24 hours after the baseline