Active — Not RecruitingNot Applicable

Singapore PREconception Study of Long-Term Maternal and Child Outcomes

Singapore1,054 participantsStarted 2015-02-27

Plain-language summary

We aim to test the following primary hypothesis that nutrition, lifestyle, and maternal emotional health prior to pregnancy and/or during the first trimester alter the expression of metabolic or neurodevelopmental endophenotypes with accompanying effects on the epigenome/transcriptome of the offspring.

Who can participate

SexALL

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Inclusion criteria

✓. Women aged 18-35 years
✓. Intention to reside in Singapore for the next 5 years
✓. Chinese, Malay, Indian or any combinations of these 3 ethnic groups
✓. Planning to conceive within 1 year
✓. Able to provide written, informed consent

Exclusion criteria

✕. Have been actively trying to conceive for more than 18 months
✕. Currently pregnant
✕. Assisted fertility, apart from those taking clomiphene alone in the past 1 month
✕. Established pre-existing diabetes (type 1 or type 2)
✕. Oral or implanted contraception, or with an IUCD in situ in the past 1 month
✕. On systemic steroids in the past 1 month
✕. On anticonvulsants in the past 1 month
✕. On HIV or Hepatitis B or C medication in the past 1 month

What they're measuring

Offspring adiposity

Timeframe: From birth until 9 years of age

Offspring neurocognitive and behavioural development

Timeframe: From 3-12 months up till 9 years of age

Trial details

NCT IDNCT03531658

SponsorKK Women's and Children's Hospital

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2029-12

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