Enoxaparin in the Prevention of Placental Insufficiency in Pregnant Women

Inclusion Criteria: * Age ≥ 18 years and * Age ≤ 45 years and * Single and confirmed pregnancy and * Intrauterine growth restriction (IUGR) history with an estimated fetal weight (ESW) \< 3rd percentile and / or * In utero fetal death (IUFD) history \> 12 weeks of amenorrhea (WA) and / or * Central Retroplacental hematoma (RPH) history \< 34 WA and / or * History of severe preeclampsia \< 34 WA and * Informed consent, written and obtained Exclusion Criteria: * Age \<18 years or * Age \> 45 years or * Multiple pregnancy or * Pregnancy \> 7 WA or * Positive immunological assessment or * Known history of Thromboembolic diseases, Hemorrhagic diseases, Systemic Lupus Erythematosus (SLE), Heparin-induced thrombocythemia (HIT), Suspicion of thrombophilia (burdened history) or an episode of Deep Vein Thrombosis (DVT) or * Anticoagulation required or * Thrombocythaemia \< 100,000 plq / µl or * Weight \> 100 kg or * Osteoporosis or * Known allergy to the study products or * Inability to ensure injections' administration or * Family history of DVT before 40 years of age or