CompletedPhase 2/3

Utility of Sodium Lactate Infusion During Septic Shock

France59 participantsStarted 2019-10-04

Plain-language summary

ULIS-1 is an open-label pilot study concerning utility of molar sodium lactate in fluid balance in septic shock patients

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Presence of septic shock * requiring vascular filling within 12 hours after introduction of Noradrenaline. Septic shock is defined as sepsis with persistent hypotension requiring the administration of vasopressors to maintain RTE \> 65mmHg. * social insurance Exclusion Criteria: * pregnancy * cardiac arrest * more than 50ml/kg of fluid loading * chronic renal failure with chronic hemodialysis or the investigators estimate a need for renal replacement therapy in the following 24hrs * child C or acute liver failure with PT\<40% (unless AVK) * plasmatic sodium \<120 or \>145mmol/l * metabolic alkalosis with pH\>7.45

What they're measuring

fluid balance

Timeframe: at 48 hours

Trial details

NCT IDNCT03528213

SponsorUniversity Hospital, Lille

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-02-21

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