Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET

Inclusion Criteria: * Age 21-55 years; * Voluntary, written, informed consent; * Physically healthy by medical history, physical, neurological, ECG and laboratory examinations; * DSM-5 criteria for Opiate Use Disorder; * Documented evidence (by urine toxicology) of 2 weeks abstinence from cocaine and 4 weeks abstinence from opiates; * For females, a negative serum pregnancy (HCG) test; * Full scale and verbal IQs \> 80 (Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV)). Exclusion Criteria: * A history of other substance dependence (e.g., alcohol, sedative hypnotics), except for nicotine; * A primary DSM-5 Axis I major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, etc.) as determined by the Structured Clinical Interview for DSM-5 (SCID-5); * A history of significant and uncontrolled medical (e.g., cardiovascular, diabetic/metabolic) or neurological (e.g., cerebrovascular, seizures, traumatic brain injury) illness; * A history of seizures; * Current use of psychotropic and/or potentially psychoactive prescription medications; * Medical contraindications to participation in a magnetic resonance (MR) imaging procedure (e.g., ferromagnetic implants/foreign bodies, claustrophobia, cardiac pacemaker, prosthetic valve, otologic implant, etc.) as recorded on the MR safety sheet; * For females, physical or laboratory (HCG) evidence of pregnancy; * PTT and PT/INR lab results not appropriate for arterial line placement; * Taking anticoagulan…