Occipital Blocks for Acute Migraine

Inclusion Criteria: * Children / Adolescents: * Males or females, ages 7 - 21, of any gender, race, or ethnicity * Diagnosis of episodic or chronic migraine with acute headache flare lasting up to 3 months unresponsive to acute medications. Patients who report that acute medications were not used during this headache flare because those medications have been ineffective for several prior headache flares will be included * Informed parental consent and subject assent * Girls, who have reached menarche, must have a negative urine or serum pregnancy test * Weight \> 25kg * Parents: * Parents or guardians of children enrolled, who speak either English or Spanish, and provide parental/guardian permission (informed consent) for their own participation * Subject (child) assent Exclusion Criteria: * Children / Adolescents: * Previous nerve block less than 3 months ago or more than 2 previous nerve blocks * Allergy to local anesthetics * Skull defect or break in the skin at the planned site of cream application or GON injection * Any investigational drug use within 30 days prior to enrollment, or 90 days prior to enrollment for medications targeted at Calcitonin Gene-Related Peptide * Pregnant or lactating females * Parents/guardians or subjects who, in the opinion of the Investigator, may be non- compliant with study schedules or procedures * Significant adverse event with prior injection or procedure * New abnormalities on physical or neurological…