Stopped: The principal investigator is leaving Yale University and will not be continuing the work at her new institution.
The investigators' objective is to understand the pathogenesis of diabetes mellitus in Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) by: 1) establishing the contributions of insulin resistance versus impaired insulin secretion, 2) investigating presence of excess glucagon signaling by measuring gluconeogenesis and glycogenolysis, and 3) investigating a potential interaction between diabetes and intraductal papillary mucinous neoplasms (IPMNs).
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Glucose tolerance status
Timeframe: Baseline
Insulin sensitivity
Timeframe: Baseline
Insulin secretion
Timeframe: Baseline
Beta cell capacity
Timeframe: Baseline
Hepatic glucose fluxes (gluconeogenesis and glycogenolysis)
Timeframe: At least 2 weeks post baseline testing