Cannabidiol and Prolonged Exposure

Inclusion Criteria: * Over the age of 18 at the time of screening. * Judged by the study physician to be in generally good health. * Meet clinical criteria for Posttraumatic Stress Disorder (PTSD) on the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5). * Negative urine pregnancy test. Exclusion Criteria: * History of significant allergic condition, significant drug-related hypersensitivity, or allergic reaction to cannabinoids. * Used cannabis, synthetic cannabinoid, cannabinoid analogue, or any CBD or THC-containing product within 30 days of eligibility screening. * Patient has had a change in psychopharmacotherapy regimen in the last 4 weeks, or has any plans to change regimen over the course of the study. * Patient is engaged in trauma-related psychotherapy for PTSD. * Current or past DSM-5 diagnosis of dissociative identity disorder, eating disorder with active purging, personality disorders, primary psychotic disorder, or bipolar affective disorder type 1. * Patient is currently prescribed medications with possible CBD-drug interactions. * History of actual suicide attempt in the last 5 years. * Unmanaged obstructive sleep apnea. * Positive drug screen for THC, barbiturates, amphetamines (if not prescribed), benzodiazepines, and/or opiates. * History of treatment for, or evidence of, moderate to severe alcohol or drug abuse within the past year or regular alcohol consumption exceeding recommended limits. * Lifetime history of Cannabis Use Disorder. * Pregnant or …