CompletedNot Applicable

Study of Dysarthria, and the Appearance of Non-dopaminergic Signs in Idiopathic PARKinson's Disease

France29 participantsStarted 2017-05-11

Plain-language summary

Pilot study: * Longitudinal follow up of the PRODY-GI cohort for parkinson's disease (PD) * Observational study of upper and lower axial symptoms' occurence in 30 PD patients in on and off drug conditions, 30 aged matched control subjects and 10 control subjects with supra nuclear palsy * Multi modal approach: functional MRI, clinical , ENT assessment, respiratory assessment, neuropsychological and gait evaluations

Who can participate

Age range18 Years – 85 Years

SexALL

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Inclusion Criteria: Parkinson's Disease group : Patients with Parkinson's Disease, who where included in the PRODYGI-1 cohort still meeting the MP criteria, Always followed in the service of neurology and pathology of the movement. Pathological control group: * Patients suffering from Richardson syndrome. * Aged over 18 Healthy control group: * Age-matched (± 5 years) * Recruited on the basis of volunteering. * free from any progressive neurological pathology after clinical examination and MoCA. Exclusion Criteria: For all groups: * Pregnant or lactating woman * Extra-neurological severe respiratory pathology * Terminal heart failure * Contraindication to MRI * Refusal / withdrawal / inability to give consent * ENT pathology.

What they're measuring

Change in the neural network between patients in OFF levodopa conditions and control subjects

Timeframe: Between two evaluation visits, on average at 3 months (baseline- 3 months)

Trial details

NCT IDNCT03517059

SponsorUniversity Hospital, Lille

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-11-12

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