UnknownNot Applicable

Effect of Periodontal Care on Rhematoid Arthritis in Uganda

Uganda152 participantsStarted 2017-09-01

Plain-language summary

this will be an RCT. to determine if non-surgical treatment for periodontitis can improve the disease activity score in 28 joints of rheumatoid arthritis in an African setting. Rheumatoid arthritis patients with periodontal disease will be randomised into an immediate intervention arm and a delayed intervention arm and both groups will be followed for two three monthly periods

Who can participate

Age range18 Years – 90 Years

SexALL

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Inclusion criteria

✓. Age 18 years or older (of either gender).
✓. RA diagnosed at least 2 year before V0.
✓. DAS28 score between 3.2 and 5.1 during the month preceding V0.
✓. No change in medication, dose, or formulation in RA treatment during the 3 months preceding V0.
✓. Available for all study visits over 6 months
✓. Presence of at least six natural teeth.
✓. Ability to give written informed consent.
✓. Having Periodontal Disease

Exclusion criteria

✕. Chronic disorder requiring chronic or intermittent use of antibiotics.
✕. Known hypersensitivity to chlorhexidine digluconate.
✕. Participation in another intervention study.
✕. Known contraindications to both amoxicillin and clindamycin.
✕. Known contraindications to dental local anesthetic.
✕. Pregnancy or lactation or intent to become pregnant

What they're measuring

change in Disease Activity score of 28 joints

Timeframe: Two three monthly follow ups

Trial details

NCT IDNCT03513263

SponsorMakerere University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-09-01

Contact for this trial

William Buwembo, PhD

+256 751 414863 wbuwembo@gmail.com

View on ClinicalTrials.gov More Rheumatoid Arthritis trials