CompletedNot Applicable

Investigating Circadian Rhythms in Youth With Persistent Tic Disorders

United States35 participantsStarted 2018-01-18

Plain-language summary

This study examines circadian rhythms and morningness-eveningness preference in youth with Persistent Tic Disorders (PTDs), including Tourette's Disorder (TD); and assesses the effects of wearable short wavelength light therapy on circadian rhythms and tic symptoms.

Who can participate

Age range13 Years – 17 Years

SexALL

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Inclusion criteria

✓. DSM-5 diagnosis of Tourette's Disorder, Persistent Motor Tic Disorder, or Persistent Vocal Tic Disorder
✓. Yale Global Tic Severity Scale Score ≥ 14 for Tourette's Disorder or ≥ 10 for Persistent Motor Tic Disorder or Persistent Vocal Tic Disorder
✓. fluency in English

Exclusion criteria

✕. Current or lifetime diagnosis of Bipolar Disorder, psychosis, or autism spectrum disorder
✕. Suicidality, severe depression or anxiety (i.e., Depression or anxiety diagnosis is more severe than Tourette's Disorder; equivalence in severity is allowed), or substance dependence, present within the past 6 months
✕. Current diagnosis of Obstructive Sleep Apnea, Restless leg syndrome, Periodic Limb Movement Disorder, or Narcolepsy
✕. Intellectual functioning below the low average range (WASI-II IQ score \< 80)
✕. Hypnotic medications, or melatonin within 8 weeks of study enrollment
✕. Changes in dosage of any psychiatric medications within the past month
✕. Behavior therapy for tics within the past 3 months
✕. Prior use of light therapy

What they're measuring

Dim Light Melatonin Onset

Timeframe: 2 weeks

Yale Global Tic Severity Scale (YGTSS)

Timeframe: 2 weeks

Trial details

NCT IDNCT03508245

SponsorUniversity of California, Los Angeles

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-06-23

View on ClinicalTrials.gov More Tourette's Disorder trials