Background:
PANS is an illness that comes on suddenly in children. The full name is Pediatric Acute-Onset Neuropsychiatric Syndrome. It can cause sudden obsessive-compulsive behaviors. It can also cause children to suddenly restricte their food intake. Researchers want to learn more about children with PANS. They also want to learn more about the illness.
Objective:
To study some disorders of behavior and emotion that start in childhood.
Eligibility:
Children 3 14 years old who have had severe obsessive-compulsive symptoms or food restriction start quickly
Design:
Parents will answer questions. The topics include:
Their child s medical history
Their child s physical and mental health
Their family history. The focus will be on neurodevelopmental and psychiatric conditions. A family tree will be drawn.
Participants will have a physical exam.
Participants may take tests on paper or computer. These will focus on thinking, memory, and behavior.
Participants and parents will give a blood sample.
Participants will have magnetic resonance imaging (MRI). A strong magnetic field and radio waves take pictures of the brain. Participants will lie on a table that slides in and out of a metal scanner.
Participants may have photos or videos taken.
Participants may have other tests. These may include heart tests, sleep tests, and lumbar puncture.
Sponsoring Institute: National Institute of Mental Health
Who can participate
Age range3 Years
SexALL
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Inclusion criteria
✓. Are 3 to 14 years of age (initial enrollment must occur prior
✓. Have a history of abrupt onset (less than 24-48 hours) of impairing OCD and/or eating restrictions.
✓. Are able to travel safely to the regional medical center where the evaluations will be conducted and are able to be examined safely over a period of one or more days.
✓. Assent to participate (if they are at least seven years old and have capacity to do so) and have legal guardians who consent to their minor child s participation.
✓. Are under the care of a primary physician in their home community.
✓. Are a biologic parent or sibling of an affected proband.
✓. Consent (or assent) to undergo study evaluations and to provide blood, microbial and genetic samples.
✓. Are 3 to 14 years of age (initial enrollment must occur prior to the participant s 15th birthday to permit prospective longitudinal evaluations)
Exclusion criteria
What they're measuring
1
Establish national database and samples repository for pediatric acute-onset neuropsychiatric syndrome (PANS)