A Study to Investigate the Interaction Between Givosiran and a 5-probe Drug Cocktail in Patients With Acute Intermittent Porphyria (AIP)

Inclusion Criteria: * 18 to 65 years old * Weight between 45kg and 110kg, inclusive, if male * Weight between 45kg and 100 kg, inclusive, if female * Diagnosis of acute intermittent porphyria (AIP) * Elevated urine PBG level * Not be pregnant or breast feeding, and must be willing to use a highly effective method of contraception Exclusion Criteria: * Clinically significant abnormal laboratory results * Experienced an acute porphyria attack within past 12 months * History of multiple drug allergies, intolerances or sensitivities * History of recurrent pancreatitis * Received an experimental drug, within 3 months of dosing * Donated or lost an excessive amount of blood within 60 days of dosing