Effect of Trimetazidine on the Improvement of Coronary Microvascular Dysfunction in Patients With… (NCT03504202) | Clinical Trial Compass
UnknownNot Applicable
Effect of Trimetazidine on the Improvement of Coronary Microvascular Dysfunction in Patients With INOCA(Ischemia and no Obstructive Coronary Artery Disease)
10 participantsStarted 2019-03-01
Plain-language summary
This is a prospective study which aims to explore the effect of Trimetazidine on the improvement of coronary microvascular dysfunction in patients with INOCA (ischemia and no obstructive coronary artery disease). Enrolled patients will be assessed SAQ(Seattle Angina Score), Canadian Angina Grade(Canadian Cardiovascular Society, CCS), Six-Minute Walk Test, CFR(coronary flow reserve) .CFR inspection with D-SPECT and pressure guide wire.Patients will receive six months Trimetazidine(35mg tid) after enrollment. And their SAQ (Seattle Angina Score), Canadian Angina Grade(Canadian Cardiovascular Society, CCS), Six-Minute Walk Test, CFR will be followed up.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* age≥18 years
* Typical angina symptoms
* Coronary angiography or coronary computed tomography examination showed no significant epicardial coronary artery stenosis (\<20%)
* Never used trimetazidine
* The CFR measured by the pressure guide wire is less than 2.0
* agree to participant the study and sign informed written consent
* available for six months follow up
Exclusion Criteria:
* Severe liver and kidney disease
* Contraindications of Trimetazidine
* Use of CYP3A inhibitors, such as diltiazem, verapamil, and other drugs that may affect CFR measurements
* QT interval extension
* Atrial fibrillation or left bundle branch block
* Left ventricular systolic dysfunction (EF \<55%)
* Coronary artery fistula
* Myocardial bridge
* Non-cardiogenic chest pain and other heart diseases
* Severe heart valve disease
* Diabetes
* Recent ACS( Acute coronary syndrome)
* Pregnancy
* Failed to complete inspection
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.