WithdrawnPhase 4

Xenon-anesthesia on Patients Undergoing Major Liver-resection

Stopped: A device would have had to be maintained. The maintenance company is insolvent; both another maintenance company and another serviced device were not available.

Germany0Started 2018-04-11

Plain-language summary

The aim of this study is to compare the postoperative outcome of patients undergoing major liver resection under xenon- compared to desflurane-anesthesia.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * ≥ 3 segments liver resection * ≥ 18 years * Both gender * American Society of Anesthesiologists (ASA) classification I-III * Written informed consent prior to study participation Exclusion Criteria: Subjects, fulfilling one or more of the following exclusion criteria will not be included in the study: * Severe pulmonary or airway disease * Severe liver disease, accompanied by a Child-Pugh class \>A * Allergy/hypersensitivity to study medications * ASA ≥ IV * Patients susceptible to malignant hyperthermia * Women who are pregnant, breast-feeding or women of childbearing potential not using adequate contraceptive methods * Patients with preeclampsia or eclampsia * Patients legally unable to give written informed consent. * Patients with risk of high oxygen demand * Patient with seriously impaired cardiac function * All contraindications for xenon anesthesia according to the summary of product characteristics LENOXe * Patient participates in a parallel interventional clinical trial during this study or receives an investigational drug within 30 days prior to inclusion into this study

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Time-course of postoperative liver injury and function

Timeframe: Within the first 7 postoperative days

Trial details

NCT IDNCT03504033

SponsorRWTH Aachen University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-09-27

View on ClinicalTrials.gov More Liver Function After Partial Liver Resection trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.