Active — Not RecruitingPhase 1

A Prospective Randomized Double Blind Trial to Assess the Effect of a Single Preoperative Dose of Gabapentin on Postoperative Opioid Consumption in Patients Undergoing Rhinoplasty

United States50 participantsStarted 2018-01-30

Plain-language summary

Adding a single preoperative dose of gabapentin to the standard pain regimen will reduce postoperative opioid consumption within the first 72 hours in patients undergoing rhinoplasty.

Who can participate

Age range18 Years

SexALL

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Exclusion criteria

✕. Patients with known allergies to medications described in this study: acetaminophen, gabapentin, and opioids (morphine, fentanyl, hydromorphone, oxycodone)
✕. Patients with chronic use of opioids due to any medical/surgical condition or those receiving any opioid medication within the 48 hours before surgery
✕. Use of gabapentin and/or pregabalin within the last 14 days prior to surgery
✕. Use of acetaminophen within the last 7 days prior to surgery
✕. Hepatic disease as documented in patient past medical history
✕. Medical history of autoimmune/neurodegenerative disease
✕. Pregnancy or breast feeding
✕. Patients with history of alcohol or substance abuse/dependency within the last 6 months

What they're measuring

Effects of Gabapentin vs Placebo in Postoperative Opioid Consumption

Timeframe: 72 hours

Trial details

NCT IDNCT03498261

SponsorOhio State University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-30

View on ClinicalTrials.gov More Pain, Postoperative trials