RecruitingNot Applicable

The Venous Distension Reflex and Orthostatic Hypertension

United States30 participantsStarted 2020-03-10

Plain-language summary

This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Are capable of giving informed consent * Are of any race or ethnicity * Are fluent in written and spoken English * Whose history and physical exam did not uncover any exclusion criteria * Are 18 years of age For subjects with elevated standing BP * Systolic BP (SBP) during standing is at least 10 mmHg \> the supine SBP * Patients with a diagnosis of stage I hypertension without other chronic diseases may be INCLUDED For normal subjects without elevated standing BP * The change in SBP by standing is within ± 5 mmHg from the supine SBP * Matched gender, similar age and BMI (within 10%) to participants with elevated standing BP * Free of acute or chronic medical conditions Exclusion Criteria: * Age \< 18 years of age * Are a pregnant or nursing woman * Are a prisoner or institutionalized individual or unable to consent * Have chronic diseases (e.g. heart, lung, neuromuscular disease, or cancer) other than stage I hypertension * Have orthostatic hypotension or a history of syncope * Current smoker * History of blood clots

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Muscle Sympathetic Nerve Activity (MSNA) in bursts/min or arbitrary units/min

Timeframe: Recorded continuously during Visit 2, the 4-5 hr Negative Pressure study visit.

Trial details

NCT IDNCT03496792

SponsorMilton S. Hershey Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-11-01

Contact for this trial

Jian Cui, PhD

717-531-1799 jcui@pennstatehealth.psu.edu

View on ClinicalTrials.gov More Blood Pressure trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.