Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury

Inclusion Criteria: * age ≥18 years old * weight ≥ 40 kg * one reading of body temperature ≥ 38.3 ºC * diagnosis of subarachnoid hemorrhage, intracerebral hemorrhage, traumatic brain injury, subdural hematoma, or ischemic stroke * admission to the Intensive Care Unit at UCSF Medical Center or Zuckerberg San Francisco General Hospital. Exclusion Criteria: * bromocriptine or acetaminophen hypersensitivity or allergy * known contraindication to bromocriptine- known ergot alkaloid hypersensitivity, known history of syncopal migraine * contraindication to nasogastric tube or swallowing pills * current diagnosis of acute liver failure, acute liver injury, or prior diagnosis of cirrhosis. acute presentation (\< 26 weeks), evidence of coagulation abnormality: international normalized ratio (INR) ≥ 2; evidence of liver damage: alanine aminotransferase (ALT) of 10 x normal value; and any degree of mental status alteration * currently being treated with intra or extravascular therapeutic hypothermia - or where therapeutic hypothermia treatment is anticipated during study period * hyperthermic syndromes: heat stroke, evidence of thyrotoxicosis, malignant hyperthermia, neuroleptic malignant syndrome, or other drug-induced hyperthermia * administration of acetaminophen or acetaminophen containing medications within 9 hours prior to fever presentation * administration of non-steroidal anti-inflammatory drugs (NSAIDs) within 6 hours prior to fever presentation or aspirin \> 300mg less tha…