Active — Not RecruitingNot Applicable

Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults (MICCHADO)

France600 participantsStarted 2018-04-20

Plain-language summary

Methodology: Prospective, multicentric, open, non-randomised, non-therapeutic, interventional study

Age range1 Year – 25 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Inclusion within 3 months after diagnosis
✓. Availability of a cryopreserved tumour sample (primary and/or metastatic and/or lymph nodes) or peripheral blood or bone marrow samples (if invasion more than 30% of lymphoblasts) for leukaemias, obtained at the time of diagnosis during a routine procedure
✓. Availability of a formalin-fixed paraffin-embedded (FFPE) tumour sample (primary and/or metastasis and/or lymph nodes), obtained at the time of diagnosis during a routine procedure (except for leukaemia patients)
✓. Age: ≤ 25 years at diagnosis
✓. Written patient informed consent, or parents or legal representative written informed consent and assent of the child and the adolescent
✓. Compulsory affiliation to a social security scheme

Number of patients with meaningful molecular genetic alterations

Timeframe: At the end of study (6 years)

Number of patients with meaningful immunological features

Timeframe: At the end of study (6 years)

Number of patients with identification of new tumor-specific genetic characteristics during follow-up (clonal evolution)

Timeframe: up to 6 years

NCT IDNCT03496402

SponsorInstitut Curie

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-04-19