Assessment of Longitudinal Changes in Endothelial Function and Oxidative Stress in Normotensive Patients With ADPKD

Inclusion Criteria: ADPKD Patients: * ADPKD (based on Ravine et al. criteria) * Class 1 B-D according to our imaging classification * Male and female subjects 18 - 40 years of age, inclusive * Estimated GFR\> 60 mL/min/m2 (CKD-Epi equation) * Systolic BP≤130mmHg without taking HTN medications * Ability to provide written, informed consent Healthy controls: * Male and female subjects 18 - 40 years of age, inclusive * estimated GFR\> 60 mL/min/m2 (CKD-EPI equation) * Systolic BP≤130mmHg without taking HTN medications * Ability to provide written, informed consent Exclusion Criteria: ADPKD Patients: * Class 2 according to our imaging classification * Concomitant systemic disease in the kidney (e.g. lupus, hepatitis B or C, amyloidosis) * Diabetes mellitus (fasting glucose \> 126 mg/dL or treatment with insulin or oral hypoglycemics). * Predicted urine protein excretion in urinalysis \>1 g/24 hrs * Abnormal urinalysis suggestive of concomitant glomerular disease * Subjects having contraindications to, or interference with MRI assessments. \[For example: ferromagnetic metal prostheses, aneurysm clips, severe claustrophobia, large abdominal/back tattoos, etc\]. * Female subjects that are pregnant Healthy controls: * Previous personal or family history of kidney disease * Concomitant systemic disease in the kidney (e.g. lupus, hepatitis B or C, amyloidosis) * Diabetes mellitus (fasting glucose \> 126 mg/dL or treatment with insulin or oral hypoglycemics). * Presence of prot…