CompletedNot Applicable

Brain Markers of Improvements in Cognitive Functioning

United States18 participantsStarted 2017-10-01

Plain-language summary

Some of the most common, persistent, and disabling consequences of traumatic brain injury affect an individual's ability to achieve personal goals. Interventions that strengthen abilities such as being able to concentrate, remember, stay calm and overcome challenges, could have far reaching benefits for Veterans. One challenge in rehabilitation is that response to training can be highly variable, and a better understanding of the neural bases for this variability could inform care. This pilot project will test the clinical behavioral effects of a cognitive skill training intervention and explore to what extent changes in markers of the brain's electrical activity (using the non-invasive technique of electroencephalograms, EEG) can explain differences in responses to skill training.

Who can participate

Age range21 Years – 55 Years

SexALL

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Inclusion Criteria: * Veterans * History of TBI (as defined by the American Congress of Rehabilitation Medicine and VA, with reported plausible mechanism of head injury, loss of consciousness with some period of posttraumatic alteration in cognition), in the chronic, stable phase of recovery (\>6 months from injury) * On stable psychoactive medications (\> 30 days) * Able and willing to participate in EEG, training and, assessments Exclusion Criteria: * Severely apathetic/abulic, aphasic, or other reasons for being unable or unwilling to participate with the training tasks * Severe cognitive dysfunction * History of neurodevelopmental abnormalities * Ongoing illicit drug or alcohol abuse * Schizophrenia * Bipolar disorder * History of other neurological disorders * Current medical illnesses that may alter mental status or disrupt participation in the study * Active psychotropic medication changes * There will be no restriction in regard to gender, race, and socioeconomic status

What they're measuring

Composite Score of Attention and Executive Functioning From a Neurocognitive Test Battery

Timeframe: Week 1, before intervention period (baseline)

Composite Score of Attention and Executive Functioning From a Neurocognitive Test Battery

Timeframe: Week 8, after the intervention period

Trial details

NCT IDNCT03490110

SponsorVA Office of Research and Development

Sponsor typeFED

Study typeINTERVENTIONAL

Primary completion2019-03-01

Results submitted2020-03-06