CompletedNot Applicable

Effect of Nitric Oxide Donors on Uterine and Subendometrial Blood Flow in Patients With Unexplained Infertility

Egypt60 participantsStarted 2017-11-01

Plain-language summary

The purpose of the study to evaluate effect of nitroglycerin trans-dermal patches on uterine and sub-endometrial blood flow in women with unexplained infertility.

Who can participate

Age range20 Years – 35 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age between 20-35 years.6
✓. Normal husband's semen analysis (WHO 2010 Criteria):
✓. Documented ovulation ( basal body temperature , mid-luteal serum progesterone ≥3 ng / ml and ultrasound monitoring of ovulation).
✓. Patent Fallopian tube and excluding uterine anomalies either by hystero-salpingogram (HSG) and/or laparoscopy.
✓. Normal hormonal profile (serum progesterone, E2, F.S.H, LH and T.S.H In the 2ND Day of menstrual cycle)

Exclusion criteria

✕. Male factor of infertility.
✕. Patients with uterine pathology as fibroids.
✕. Tubal factor of infertility diagnosed by hysterosalpingography (HSG) or laparoscopy.
✕. Patients with any contraindications for NO such as chronic liver and renal disease, known cardiac disease and migraine.
✕. Diagnosis of PCO based on Rotterdam criteria, two out of three of the following are required to make the diagnosis (Rotterdam, 2004):
✕. Conditions that mimic PCOS; disorders that cause oligo/anovulation and/or hyperandrogenism, such as:
✕. Women who had any medical comorbidity (e.g. autoimmune disease or diabetes mellitus) and those who have been using medications to induce ovulation or medications known to affect the VEGF concentration (NSAIDs) were not included in the study.

What they're measuring

Three dimensional power Doppler

Timeframe: from day 10 of menstrual cycle until the follicle reached ≥18 mm

Trial details

NCT IDNCT03481582

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-03-01

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