TerminatedNot Applicable

Effectiveness of Bronchodilator Nebulization With and Without Noninvasive Ventilation in COPD

Stopped: Poor recruitment

Singapore11 participantsStarted 2018-04-10

Plain-language summary

The study aim to evaluate effectiveness of two bronchodilator nebulization strategies in patients with acute decompensated type 2 respiratory failure due to acute exacerbation of chronic obstructive pulmonary disease..

Who can participate

Age range21 Years – 99 Years

SexALL

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Inclusion criteria

✓. Age ≥21 years.
✓. Known or suspected COPD (defined by a ratio of Forced Expiratory Volume in 1 second (FEV1) to Forced Vital Capacity (FVC) of less than 0.7).
✓. Acute decompensated type 2 respiratory failure (ABG pH ≤ 7.35 and PaCO2\>45mmHg).
✓. Clinical decision made to start NIV.

Exclusion criteria

✕. Other acute decompensated type 2 respiratory failure related conditions (e.g. neuromuscular, heart failure etc.).
✕. Pneumonia present in the chest radiograph.
✕. Other conditions which may change lung impedance (e.g. heart failure or lung fibrosis).

What they're measuring

Difference in mean end-expiratory lung volumes between the two nebulization methods.

Timeframe: At baseline (approximately 15min after starting NIV) to approximately 15min after restarting (or continuing NIV) following the nebulization.

Trial details

NCT IDNCT03481543

SponsorNational University Health System, Singapore

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-11-12

View on ClinicalTrials.gov More Chronic Obstructive Pulmonary Disease (COPD) trials