Long Term Morbidity and Quality of Life in Retroperitoneal Sarcomas

Plain-language summary

No prospective data exist about long term morbidity and quality of life after multivisceral surgical resection for retroperitoneal soft tissue sarcoma (RSTS). In order to assess the safety of this surgical approach and the effect on the Quality of Life over the long period we propose a prospective observational study. The hypothesis is that the surgical treatment has no significant impact in determining a lower Quality of Life in the long term. Objectives Primary objective Estimate the difference between baseline and 4 and 12 months scores of the "global health status / QoL" scale in patients primarily treated for localized RSTS, as determined in QLQ-C30 version 3.0. Secondary objectives * Evaluate the long term morbidity of aggressive surgical approach to RSTS in terms of renal failure. * Evaluate the difference between baseline and 4 and 12 months scores of DN4 / LEFS / BPI questionnaires. * Evaluate the difference between baseline and 4 and 12 months scores of the following scales from QLC-C30: PF2, RF2, EF, CF, SF, FA, FI. * Evaluate the difference between baseline and 4 and 12 months scores of the following scales and single items from QLC-C29: Blood and mucus in stool, Stool frequency, Sexual interest, Impotence, Dyspareunia. * To correlate the surgical resection pattern (number and type of organs resected) and the tumor features (size, grading and histological subtype) with the long-term morbidity and quality of life. Eligibility Inclusion criteria * Adult patients (age \> 18 years) with primary localized RSTS surgically treated at our institution * Written, voluntary, informed consent Exclusion criteria \- Recurrent disease

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