CompletedPhase 2/3

Estradiol Pretreatment With Misoprostol in Second Trimester Miscarriage

Egypt200 participantsStarted 2018-03-21

Plain-language summary

To compare the effectiveness of estradiol pretreatment with misoprostol and vaginal misoprostol alone in induction of second trimestr miscarriage.

Who can participate

Age range

18 Years – 40 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Maternal age more than 18 years old (age of legal consent). * Gestational age between 12-26 weeks. * Hb level \> 10 g/dL. * BMI between 25 kg/m2 and 35 kg/m2. * Missed abortion. * Living fetus with multiple congenital malformations incompatible with life. * PPROMS with drained liquor and parents are consenting for termination of pregnancy. Exclusion Criteria: * Maternal age less than 18 years old. * Gestational age less than 12 weeks or more than 26 weeks. * Hb level \< 10 g/dL. * Scared uterus (previous myomectomy - cesarean section - hysterectomy and ruptured uterus). * Polyhydramnios. * Anencephaly. * Fibroid uterus. * BMI less than 25 kg/m2 and more than 35 kg/m2. * Coagulopathy. * Previous attempts for induction of abortion in the current pregnancy. * Allergy to misoprostol or estradiol. * Placenta previa. * Medical disorder that contraindicate induction of abortion (e.g. heart failure).

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Duration of induction of abortion

Timeframe: 24 hours

Trial details

NCT IDNCT03479879

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-12-20

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