CompletedPhase 2/3

Estradiol Pretreatment With Misoprostol in Second Trimester Miscarriage

Egypt200 participantsStarted 2018-03-21

Plain-language summary

To compare the effectiveness of estradiol pretreatment with misoprostol and vaginal misoprostol alone in induction of second trimestr miscarriage.

Who can participate

Age range18 Years – 40 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Maternal age more than 18 years old (age of legal consent). * Gestational age between 12-26 weeks. * Hb level \> 10 g/dL. * BMI between 25 kg/m2 and 35 kg/m2. * Missed abortion. * Living fetus with multiple congenital malformations incompatible with life. * PPROMS with drained liquor and parents are consenting for termination of pregnancy. Exclusion Criteria: * Maternal age less than 18 years old. * Gestational age less than 12 weeks or more than 26 weeks. * Hb level \< 10 g/dL. * Scared uterus (previous myomectomy - cesarean section - hysterectomy and ruptured uterus). * Polyhydramnios. * Anencephaly. * Fibroid uterus. * BMI less than 25 kg/m2 and more than 35 kg/m2. * Coagulopathy. * Previous attempts for induction of abortion in the current pregnancy. * Allergy to misoprostol or estradiol. * Placenta previa. * Medical disorder that contraindicate induction of abortion (e.g. heart failure).

What they're measuring

Duration of induction of abortion

Timeframe: 24 hours

Trial details

NCT IDNCT03479879

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-12-20

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