A Study of Fluoroquinolones Exposure and Collagen-Related Serious Adverse Events

Inclusion Criteria: * Have evidence of at least 1 instance of Achilles Tendon Rupture (ATR) or Retinal Detachment (RD) or Aortic Aneurysm and Dissection (AAD) * Have at least 1 exposure to Fluoroquinolones or any of the other antibiotics (amoxicillin, azithromycin, trimethoprim and trimethroprim/sulfamethoxazole) or febrile illness not treated with antibiotic * Have at least 1 year of continuous enrollment with pharmacy benefits prior to the ATR, RD or AAD Exclusion Criteria: ATR, AAD and RD cohorts: \- Participants who experience the index event while within a time-at-risk window for more than one exposure type. (The exposure types in this study include FQ as a class, amoxicillin, azithromycin, trimethoprim, trimethroprim/sulfamethoxazole, and febrile illness not treated with antibiotics. Events while within a time-at-risk window of two or more exposure types cannot be associated with any one exposure. Participants are therefore excluded from the study) For ATR and AAD cohorts: * Have inherited disorders of connective tissue, specifically: Ehlers-Danlos syndrome, epidermolysis bullosa, Marfan syndrome, osteogenesis imperfecta * Have an ATR or AAD event prior to index, during the 1-year pre-index period For RD cohort: * Have cataract surgery prior to index * Have iridotomy or iridectomy prior to index