CompletedNot Applicable

Pilot Study of Triphala and Rubia Cordifolia on Gut Microbiome and Skin

United States35 participantsStarted 2018-03-12

Plain-language summary

Few studies have assessed the effects of Triphala and Rubia Cordifolia from a skin biophysical perspective. Here, we aim to understand how these herbs can modulate the skin's barrier properties and the gut microbiome.

Who can participate

Age range

18 Years – 60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Age 18 to 60 years of age
. Subject must be able to read and comprehend study procedures and consent forms.

Exclusion criteria

. Subject should be generally healthy and have no smoking history in the past one year.
. Subjects must have no history of diabetes, metabolic syndrome, known cardiovascular disease, malignancy, kidney disease, or chronic steroid use.
. Those who are unable to discontinue topical medications for two weeks.
. Those who are unable to discontinue systemic antibiotics or oral probiotics for one month prior starting the study.
. Those who are unable to discontinue their Triphala and Rubia Cordifolia regimen for one month prior to starting study.
. Subjects who are postmenopausal
. Those who are pregnant or breastfeeding
. Those that are prisoners or cognitively impaired

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Sebum excretion rate

Timeframe: 4 weeks +/- 1 week

Stool microbiome diversity via stool sample

Timeframe: 4 weeks +/- 1 week

Trial details

NCT IDNCT03477825

SponsorUniversity of California, Davis

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-08-16

View on ClinicalTrials.gov More Sebum Production trials