CompletedNot Applicable

Pilot Study of Triphala and Rubia Cordifolia on Gut Microbiome and Skin

United States35 participantsStarted 2018-03-12

Plain-language summary

Few studies have assessed the effects of Triphala and Rubia Cordifolia from a skin biophysical perspective. Here, we aim to understand how these herbs can modulate the skin's barrier properties and the gut microbiome.

Who can participate

Age range18 Years – 60 Years

SexALL

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Inclusion criteria

✓. Age 18 to 60 years of age
✓. Subject must be able to read and comprehend study procedures and consent forms.

Exclusion criteria

✕. Subject should be generally healthy and have no smoking history in the past one year.
✕. Subjects must have no history of diabetes, metabolic syndrome, known cardiovascular disease, malignancy, kidney disease, or chronic steroid use.
✕. Those who are unable to discontinue topical medications for two weeks.
✕. Those who are unable to discontinue systemic antibiotics or oral probiotics for one month prior starting the study.
✕. Those who are unable to discontinue their Triphala and Rubia Cordifolia regimen for one month prior to starting study.
✕. Subjects who are postmenopausal
✕. Those who are pregnant or breastfeeding
✕. Those that are prisoners or cognitively impaired

What they're measuring

Sebum excretion rate

Timeframe: 4 weeks +/- 1 week

Stool microbiome diversity via stool sample

Timeframe: 4 weeks +/- 1 week

Trial details

NCT IDNCT03477825

SponsorUniversity of California, Davis

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-08-16

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