TerminatedPhase 4

Fentanyl and Crushed Ticagrelor in Percutaneous Coronary Intervention

Stopped: Researcher stopped study due to slow accrual rate

United States45 participantsStarted 2018-04-18

Plain-language summary

During a percutaneous coronary intervention (PCI), Fentanyl is commonly used for sedation. Ticagrelor is also routinely used as anti-platelet agent during PCI. However, a recent study has demonstrated the decrease in effectiveness of Ticagrelor when administered along with Fentanyl. Hence this study was designed to further assess the interaction between crushed vs non crushed Ticagrelor and Fentanyl given during PCI procedures.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Undergoing clinically indicated elective or non-elective PCI * Able to swallow oral medications Exclusion Criteria: * Contraindications to ticagrelor or fentanyl (or other opiates) * Pregnancy * Any use of P2Y12 inhibitors within 14 days * Known coagulation disorders * Pre-procedural treatment with an anticoagulant (oral anticoagulant or low molecular weight heparin) * Platelet count \< 100,000/mm3 * Impaired renal function (Estimated glomerular filtration \< 45 ml/min/1.73 m2) * Impaired hepatic function (Based on medical history) * Prior or planned transcatheter aortic valve replacement

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Area Under the Platelet Function Testing (PFT)-Time Curve (AUC0-6) for the First 6 Hours After the Loading Dose of Ticagrelor

Timeframe: 6 hours after the loading dose of Ticagrelor

Trial details

NCT IDNCT03476369

SponsorThe Guthrie Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-01-23

Results submitted2025-12-30

View on ClinicalTrials.gov More Percutaneous Coronary Intervention trials