Stanford Regulating Circuits of the Brain Study- Ketamine

Inclusion Criteria: * Ages 18-55 years * At least 2 prior uses of ketamine when aged 18+ * BMI within healthy range (18-30) * Ability to speak, read, or understand English Exclusion Criteria: * Current active suicide ideation or history of suicide attempts * Current mood, anxiety, eating, psychotic, or substance use disorder * Lifetime psychotic or bipolar disorder * Schizophrenia in a first degree relative * Current use of psychotropic medication * Prior adverse ketamine response * Allergy or hypersensitivity to ketamine * Use of ketamine in past 7 days * Cannabis use in the past 7 days, illicit recreational drug use in the 48 hours prior to sessions, and/or alcohol use in the 24 hours prior to sessions * Concurrent use of any medications that might increase the risk of participation (e.g., drug interactions) * History of epilepsy, convulsions, seizures, LOC \>10 min * Renal/hepatic impairment * Hypertension (Stage 1 defined as systolic blood pressure \>140 mmHg or diastolic blood pressure \>90 mmHg on 2 of 3 measurements at least 15 min apart at initial screening; systolic blood pressure \>155 mmHg or diastolic blood pressure \>99 mmHg on 2 of 3 measurements at least 15 min apart during infusion visits) * Heart rate \<50 bpm or \>150 bpm at initial screening * Chronic congestive heart failure, tachyarrhythmias, myocardial ischemia assessed via EKG at initial screening * EKG QTcF intervals \>430 ms for men and \>470 ms for women * Direct physical access to or routine hand…