CompletedNot Applicable

Neuroplasticity in Auditory Aging_Project 2 Aims 1 and 2

United States405 participantsStarted 2018-02-21

Plain-language summary

Millions of elderly adults in the USA have age related hearing loss (ARHL), a malady that affects half of adults 60-69 years, and the majority of older adults. This hearing loss not only impacts communication and functional ability, but also is strongly associated with cognitive decline and decreased quality of life. This project aims to develop effective strategies to compensate and reverse this process through a deeper understanding of plasticity and adaptive auditory function, and how to engage it and harness it to remedy ARHL.

Who can participate

Age range18 Years – 85 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * native speaker of English * normal cognitive function as measured on Montreal Cognitive Assessment * pass screening auditory brainstem response test to make sure they have recordable brainwaves to acoustic stimuli * age and hearing sensitivity: * young normal-hearing listeners, 18-35 years, hearing thresholds less than 25 decibels (dB) HL from 250 - 4000 Hz; * older normal-hearing listeners, 65-85 years, hearing thresholds less than 25 dB HL, from 250-4000 Hz; * older hearing-impaired listeners, 65-85 years, with mild-to-moderate, high frequency sensorineural hearing loss; * high school diploma Exclusion Criteria: * absence of conductive hearing loss and middle-ear disease * no neurological disease * severe or profound hearing loss * non-native speaker of English * cognitive impairment

What they're measuring

Improvement in behavioral auditory temporal processing measures (Aim 1)

Timeframe: completion of study, approximately 30 months

Improvement in recognition of trained stimuli - fast speech (Aim 2)

Timeframe: completion of study, approximately 24 months

Trial details

NCT IDNCT03475043

SponsorUniversity of Maryland, College Park

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-05-31