Investigation of Cocaine Addiction Using mGluR5 PET and fMRI

Inclusion Criteria: * All participants: * Age 21 - 60 years * Provide voluntary, written, informed consent * Physically healthy by medical history, physical, neurological, ECG, and laboratory examinations * For females: non-lactating, no longer of child-bearing potential or agreeing to practice effective contraception during the study (e.g., established use of oral, injected or implanted hormonal methods of contraception; placement of an intrauterine device \[IUD\] or intrauterine system \[IUS\]; barrier methods: condom or occlusive cap \[diaphragm or cervical/vault caps\] with spermicidal foam/gel/film/cream/suppository; male partner sterilization; true abstinence when this is in line with the preferred and usual lifestyle of the subject), and a negative serum pregnancy test * Participants with a cocaine use disorder: * DSM-5 criteria for moderate or severe cocaine-use disorder * Recent street cocaine use in excess of quantities used in the current study * Intravenous and/or smoked (crack/freebase) cocaine use * Positive urine toxicology screen for cocaine * Healthy comparison participants: * Successful completion of an \[18F\]FPEB scan as part of another Yale approved protocol as a healthy control/comparison subject Exclusion Criteria: * All participants: * Any condition that, in the opinion of investigators, would prevent compliance with the study protocol * A history of significant medical or neurological illness (e.g., coronary artery disease…