CompletedPhase 4

Fibrinolysis Compared to Thoracoscopy for Pleural Infection

United States32 participantsStarted 2017-11-01

Plain-language summary

The purpose of this prospective randomized clinical trial is to compare two currently accepted standard-of-care treatment strategies: Medical thoracoscopy as compared to instillation of intrapleural tissue Plasminogen Activator (TPA) and human recombinant Deoxyribonuclease (DNase) for the management of empyema or complicated parapneumonic effusion (CPPE) in adults.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Subjects \>18 years old with: Evidence of empyema or complex parapneumonic effusion Exclusion Criteria: Age \<18 years Pregnancy Inability to give informed written consent Previous thoracic surgery or thrombolytic therapy for pleural infection Medical thoracoscopy cannot be performed within 48 hours Hemodynamic instability or severe hypoxemia Non corrected coagulopathy Homogeneously echogenic effusion on pleural ultrasonography

What they're measuring

Duration of Hospital Stay After Intervention

Timeframe: 12 week follow up period

Trial details

NCT IDNCT03468933

SponsorTulane University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-12-30

Results submitted2020-12-05

View on ClinicalTrials.gov More Pleural Infection trials