COMPLETE: International Acute Ischemic Stroke Registry With the Penumbra System Aspiration Including the 3D Revascularization Device

Inclusion Criteria: * Patient age ≥ 18 * Pre-stroke mRS 0-1 * Patient experiencing acute ischemic stroke secondary to intracranial large vessel occlusion who are eligible for mechanical thrombectomy using the Penumbra System * Planned frontline treatment with Penumbra System * Signed informed consent per Institution Review Board/Ethics Committee Exclusion Criteria: * Any comorbid disease or condition expected to compromise survival or ability to complete follow-up assessments through 90 days. * Currently participating in an investigational (drug, device, etc) clinical trial that will confound study endpoints. Patients in observational, natural history, and/or epidemiological studies not involving intervention are eligible.