UnknownNot Applicable

Evaluation of Stress Sensitivity and Hyperemotivity in Epilepsy Compared to and a Group of Healthy Volunteers

France120 participantsStarted 2018-03-08

Plain-language summary

Recently, a possible subtype of temporal lobe epilepsy (TLE) has been proposed: this subtype presents ipsilateral amygdala enlargement (AE) without any other lesion. However, little is known about its clinical and psychiatric phenotype. The amygdala seems to play a major role in stress related disorders (including perception of stress). The hypothesis in this study is that patients with TLE-AE more frequently report emotional distress as a seizure-precipitating factor than any other epileptic patient.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: \- For all epileptic patients: Age between 18 and 65. Epilepsy (TLE or not) followed by an epileptologist. \- For TLE-AE: An AE identified on the MRI by an expert neuroradiologist. MRI must be less than one year. \- For non AE epileptic patients: No AE reported in the MRI by an expert neuroradiologist. Exclusion Criteria: * Any mental disorder. * Any diabetes * Beta-blockers * Neuroleptics * Any neurologic diseases for the healthy volunteers.

What they're measuring

Score on the scale of emotional seizure precipitant the outbreak

Timeframe: 30 minutes

Trial details

NCT IDNCT03464370

SponsorUniversity Hospital, Toulouse

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-03

Contact for this trial

Marie DENUELLE, MD

5 61 77 79 24 denuelle.m@chu-toulouse.fr

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