CompletedNot Applicable

Acute Posttraumatic Osteomyelitis in Patients With High-energy Tibial Fractures and Biomarkers

86 participantsStarted 2011-01-01

Plain-language summary

The present trial was aimed to identify which biomarkers could be associated in perioperative period after surgical treatment of tibial fracture to the development of POM.

Who can participate

Age range15 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * high-energy injury to proximal, shaft or distal tibia, * tibial fracture requiring primary surgical treatment /ORIF Exclusion Criteria: * ankle fracture, * patella fracture, * avulsion fracture of the knee, * malignant neoplasm and pathological tibial fracture, * systemic autoimmune disease of connective tissue, * immature patients under 15 years of age (children), * immunocompromised patients.

What they're measuring

Measurement of biomarkers CRP, PCT, WBC on ADD, POD1, POD4

Timeframe: perioperative period

Assessment of patients' immune status

Timeframe: perioperative period

Determination of cytokines level in serum: tumor necrosis factor (TFN-alpha), interleukin-6 (IL-6), interleukin-10 (IL-1) and lymphocyte populations

Timeframe: perioperative period

Trial details

NCT IDNCT03459261

SponsorUniversity Medical Centre Ljubljana

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2013-12-31

View on ClinicalTrials.gov More Osteomyelitis Tibia trials