Determining how memory T helper type 2 (Th2) initiate recall responses to aeroallergens has the potential to change the therapeutic approach to allergic asthma, the most common asthma subtype. \~5-10% of effector Th2 cells recruited into the lung give rise to long-lived tissue resident memory cells that are poised to respond upon allergen re-exposure.Consequently, targeting memory Th2 cell activation is an attractive therapeutic strategy. However, it is not well understood how allergen inhalation initiates a memory Th2 cell response in the lung. The focus of this new study on the role of lung-resident memory Th2 cells in orchestrating the recall response to allergen in the lung, including the recruitment and activation of circulating Th2 cells, is a natural, timely and exciting extension of the investigators' ongoing Allergen Challenge Protocol.
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The phenotype of Th2-Trm recovered from the airway mucosa
Timeframe: This is a single time point study with all information obtained at the time of bronchoscopy defined as Day 0.
The transcriptional profile of Th2-Trm recovered from the airway mucosa
Timeframe: This is a single time point study with all information obtained at the time of bronchoscopy defined as Day 0.