Effect of CPAP Therapy on LPR Among Patients With OSAS

Inclusion Criteria: * Patients have to stop proton pump inhibitors (PPI) therapy 1 month before enrollment in the study. * To be eligible as LPR patients in our study, patients must have presented a RSI score \> 13 and a RFS score \> 7. These thresholds were highly correlated with pathological pH monitoring (pH \< 4) Exclusion Criteria: * Noncompliance for CPAP Use: According to the standard Medicare criteria to define CPAP compliance, the patients who demonstrated CPAP use ≥ 4 h/ night for ≥ 70% of the nights are considered compliant. * Antireflux therapy during the period of the study.