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A Comparative Study of Different Hypothermic Circulatory Arrest Strategies on Aortic Surgery.

China80 participantsStarted 2018-08-03

Plain-language summary

By comparing the clinical outcome of patients underwent different hypothermic circulatory arrest (mild hypothermic versus moderate hypothermic) during aortic arch surgery, this study aims to determine the optimal hypothermic circulatory arrest strategy for aortic surgery.

Who can participate

Age range18 Years – 70 Years

SexALL

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Inclusion criteria

✓.Patients with confirmed diagnosis (i.e.aortic dissection, marfan syndrome, aortic arch aneurysm and so on), which require total aortic arch replacement.

Exclusion criteria

✕. Preoperative heart attack or coma.
✕. Patients with surgical contraindication, including but not limited to severe cardiac,pulmonary,renal or hepatic insufficiency.
✕. Pre-existing heart condition or neurological disease.
✕. Variation of aortic arch or its branch vessels.
✕. Patient is currently on anticoagulation therapy or has other medical condition that compromises the coagulation.
✕. Patient with active infection.
✕. Allergy to anaesthetic or contrast agent.
✕. Pregnant or lactating female.

What they're measuring

Mortality

Timeframe: 3 months within surgery.

Re-thoracotomy

Timeframe: Through the hospitalization, an average of 4 weeks.

Neurological disorder

Timeframe: Through the hospitalization, an average of 4 weeks.

Trial details

NCT IDNCT03454633

SponsorXiaoping Fan. MD

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-02-15

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