MRgFUS in the Treatment of Osteoarthritic Knee Pain

Inclusion Criteria: * Male and female aged 50-80 years * Activity-related joint pain * Patients who have not responded to previous treatments and patients candidate for surgery * Kellgren-Lawrence score 2-4 on X-rays * Patients able to give their informed consent Exclusion Criteria: * Prior surgery in the past 12 months or previous local treatment in the past 3 months * Changes in medications used during the previous 2 months * Corticosteroid use for more than 3 months within the preceding year * Rheumatologic and neurological disorders * Fibromyalgia * Trauma, fracture or osteomyelitis of the investigated joints within the preceding year * Pregnancy * Patients with large scars potentially included in the ultrasound beam path * General contraindications to MRI and/or to anaesthesiological procedures * Presence of internal hardware or device potentially affecting MR thermometry * Patients involved in other clinical studies